Behind Vann, the only player to win Big 12 Conference Sixth Player of the Year twice, the Sooners took charge by scoring the last six points of the third quarter and the first four of the fourth for a 66-57 lead.
Ole Miss (1-1) got within five but the No. 23 Sooners (2-0) pulled away again. Vann hit a 3-pointer and followed it up with a three-point play on the next possession before her layup made it 80-66 with 1:43 to play.
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